Fig. 5.

(a) Mean percent change in Ktrans from baseline showing a significant decrease in both SU arms at Day 3 (SU, P=.04; SURT, P=.04) and a sustained drop in Ktrans in the SURT arm. (b) Mean percent change in Kep showing a significant decrease in both SU arms at Day 3 (SU, P=.01; SURT, P=.02). (c) Mean percent change in precontrast tumor T1 from baseline. (d) Mean percent change in Ktrans when population T1 and individual mouse T1 are used in the modified Tofts model for each treatment arm showing less variability with individual T1.