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Rapid and persistent desensitization to the vasoconstrictor effects of ANG II. Representative trace (left) and summary (right) data showing that vasoconstriction in response to a second application of ANG II (100 nM), administered after 20 min, is significantly blunted compared with the first administration (N = 3 animals, n = 6 pial arteries; paired t-test, *P < 0.05).
