Table 3.
Percent nucleotide (below the diagonal) and amino acid (above the diagonal) sequence identities between hepevirusesa
| Hepevirus lineage (no. of strains compared) | % identity |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Bat | Avian | Rodent | HEV genotype 1 | HEV genotype 2 | HEV genotype 3 | HEV genotype 4 | Rabbit | Unassigned boar | Trout | |
| Bat (7) | 78.9–100 | 67–72.5 | 58.3–63.9 | 57.4–62 | 57.4–62 | 58.3–63.9 | 63–64.8 | 58.3–62 | 59.3–68.5 | 44–46.8 |
| 70.3–100 | ||||||||||
| Avian (4) | 94.5–100 | 59.3–62 | 60.2–62 | 59.3–60.2 | 60.2–63 | 62–63.9 | 61.1–63 | 62.3–65.7 | 45.0 | |
| 60.6–65.4 | 78.3–89.3 | |||||||||
| Rodent (5) | 90.7–96.3 | 68.5–75.0 | 68.5–72.2 | 65.7–73.1 | 71.3–73.1 | 66.7–72.2 | 67–71.3 | 39.8–43.5 | ||
| 56.5–60.8 | 53.7–61.4 | 77.2–95.4 | ||||||||
| HEV genotype 1 (4) | 96.3–99.1 | 87–88.9 | 80.6–86.1 | 77.8–83.3 | 83.3–87 | 82.4–85.8 | 41.7–43.5 | |||
| 58–63.6 | 59.6–62.7 | 63.3–66.7 | 93.8–98.8 | |||||||
| HEV genotype 2 (1) | 100 | 83.3–85.2 | 81.5 | 86.1–87 | 83–84.3 | 42.6 | ||||
| 54.6–60.5 | 57.7–61.7 | 62.0–63.9 | 76.5–77.5 | 100 | ||||||
| HEV genotype 3 (13) | 91.7–100 | 82.4–86.1 | 90.7–95.4 | 83–88 | 45.4–48.1 | |||||
| 57.4–63.9 | 57.4–64.8 | 58.6–66 | 71.9–76.9 | 72.2–76.5 | 78.1–99.4 | |||||
| HEV genotype 4 (6) | 94.4–100 | 82.4–85.2 | 84–88.9 | 44.4–45.4 | ||||||
| 56.8–64.2 | 59.6–65.1 | 61.4–65.7 | 70.1–74.4 | 69.4–72.5 | 70.7–78.4 | 82.7–97.8 | ||||
| Rabbit (3) | 96.3–97.2 | 81.1–85.2 | 43.5–44.4 | |||||||
| 56.8–63 | 57.4–63.9 | 60.2–63.6 | 70.7–76.2 | 71.6–75.3 | 77.5–83.3 | 70.4–75.9 | 86.4–88.3 | |||
| Unassigned boar (2) | 88.7 | 44.4–45.3 | ||||||||
| 55.9–63.9 | 60.8–64.8 | 59.6–64.2 | 72.7–76.2 | 73–74.4 | 71.1–78.1 | 74.5–78.7 | 71.3–72.2 | 76.5 | ||
| Trout (1) | 100 | |||||||||
| 47.4–50.5 | 46.5–50.8 | 45.4–49.1 | 44.4–46 | 50.3 | 48.5–51.5 | 48.8–50.6 | 48.5–51.2 | 47.5–51.2 | 100 | |
Evolutionary analyses were conducted with MEGA5 (66). GenBank accession numbers are as follows: JQ001744 to JQ001749 and JQ071861 for bat HEV; AM943647, EF206691, AY535004, and GU954430 for avian hepevirus; GU345042, GU345043, GQ504009, GQ504010, and JN040433 for rodent HEV; AF459438, DQ459342, D11092, and L08816 for HEV genotype 1; M74506 for HEV genotype 2; EU723512, EU375463, AB291958, AB248520, AB248521, FJ998008, FJ705359, AB089824, AB443624, AB291956, AB591734, AB189071, and AB301710 for HEV genotype 3; AB097812, AB097811, AB480825, AB220974, AB521805, and GU119960 (genotype 4a) for HEV genotype 4; FJ906895, FJ906896, and GU937805 for rabbit HEV; AB602441 and AB573435 for unassigned boar HEV; and NC_015521 for trout HEV. Boldface type indicates percent nucleotide identity, and lightface type indicates percent amino acid identity.