Table 2.
Five Year Changes in Geographic Atrophy Measures by Type of Lesions.
| All Eyes | Classic Single | Multi-Focal | Merged | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean (SE)a or % | N | Mean (SE)a or % | N | Mean (SE)a or % | N | Mean (SE)a or % | P-valueb | |
| Change in total area (mm2) | 53 | 6.35 (1.01) | 19 | 2.24 (1.19) | 7 | 11.97 (1.69) | 27 | 8.42 (1.02) | .001 |
| Change in disc areas | 53 | 2.45 (0.41) | 19 | 0.82 (0.49) | 7 | 4.66 (0.71) | 27 | 3.27 (0.42) | .002 |
| Change in GLD (µm) | 53 | 1434 (225) | 19 | 710 (232) | 7 | 3822 (353) | 27 | 1414 (198) | <.001 |
| Change in VA (# of letters) | 50 | −16.69 (3.26) | 17 | −10.47 (5.26) | 7 | −21.67 (7.98) | 26 | −19.74 (4.29) | .36 |
| Progression to center point | 19 | 47.4% | 9 | 22.2% | 6 | 83.3% | 4 | 50.0% | .08 |
N= number of eyes with change data, numbers differ due to missing data
a
Standard errors corrected for multiple observations within the same person (see Methods)
b
P-value is type 3 test from the mixed effect models for continuous measures and Fisher’s exact test for progression to the center point; p-values test for difference amongst the 3 geographic atrophy types
Abbreviations: SE=standard error; GLD= greatest linear dimension; VA=visual acuity