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. Author manuscript; available in PMC: 2024 Mar 2.
Published in final edited form as: Mol Cell. 2023 Jan 19;83(5):660–680. doi: 10.1016/j.molcel.2022.12.031

Figure 1: DDRi overwhelms cellular DNA damage responses and induces cancer cell death.

Figure 1:

Targeted DDRi agents inactivate key DNA repair pathways, causing accumulation of double-stranded DNA breaks. This double-stranded DNA break accumulation, combined with increased dependence on error-prone repair mechanisms, overwhelms cellular damage tolerance and promotes cancer cell death.