Table 8.
Multivariate analysis of visual acuity at last observation in REFLECT
| Number of eyes | LS mean [95% CI] (logMAR) | Effect estimate [95% CI] | P valueb | |
|---|---|---|---|---|
| Bilaterally treated versus natural history | ||||
| Treatment status | − 0.45 [− 0.59; − 0.32] | < 0.0001 | ||
| Treated | 96 | 1.25 [1.12; 1.38] | ||
| Natural history (reference) | 336a | 1.71 [1.62; 1.79] | ||
| Covariates | ||||
| Gender (reference = male) | − 0.0986 [− 0.2402; 0.043] | 0.1713 | ||
| Ethnicity (reference = non-Asian) | − 0.5666 [− 0.8636; − 0.2695] | 0.0002 | ||
| Age at onset of vision loss | 0.0019 [− 0.0031; 0.0069] | 0.4539 | ||
| Duration of follow-up | 0.0008 [0.0003; 0.0012] | 0.0010 | ||
| Interaction Age × Ethnicity | 0.0124 [0.0017; 0.023] | 0.0231 | ||
| Unilaterally treated versus natural history | ||||
| Treatment status | − 0.35 [− 0.49; − 0.22] | < 0.0001 | ||
| Treated | 100 | 1.35 [1.21; 1.49] | ||
| Natural history (reference) | 336a | 1.70 [1.62; 1.79] | ||
| Covariates | ||||
| Gender (reference = male) | − 0.081 [− 0.2316; 0.0696] | 0.2901 | ||
| Ethnicity (reference = non-Asian) | − 0.6206 [− 0.9261; − 0.3152] | < 0.0001 | ||
| Age at onset of vision loss | − 0.0002 [− 0.0055; 0.0052] | 0.9553 | ||
| Duration of follow-up | 0.0008 [0.0003; 0.0012] | 0.0014 | ||
| Interaction Age × Ethnicity | 0.0113 [0.0003; 0.0223] | 0.0440 | ||
CI confidence interval, logMAR logarithm of the minimal angle of resolution, LS least squares
a72 natural history eyes were excluded from the analysis because of missing gender data
bRepeated measure analyses taking into account the inter-eye correlation of each patient