Table 7.
Visual acuity at last observation in REFLECT
| Treated (REFLECT) | Natural history (N = 408 eyes) | ||
|---|---|---|---|
| Bilaterally treated (N = 96 eyes) | Unilaterally treated (N = 100 eyes) | ||
| Visual acuity (logMAR) | |||
| Median | 1.40 | 1.40 | 1.70 |
| Mean (SD) | 1.32 (0.54) | 1.45 (0.60) | 1.68 (0.61) |
| 95% CI (mean) | [1.21; 1.43] | [1.33; 1.57] | [1.62; 1.74] |
| P values versus NH (KW/ANCOVAa) | < 0.01/< 0.01 | < 0.01/< 0.01 | – |
| Mean difference versus NH [95% CI]a | − 0.355 [− 0.488; − 0.222] | − 0.228 [− 0.361; − 0.095] | – |
| Response rate (logMAR ≤ 1.6) | |||
| n (%) [95% CI] | 76 (79.2%) [69.7; 86.8] | 67 (67.0%) [56.9; 76.1] | 181 (44.4%) [39.5; 49.3] |
| P values versus NH (C/GLMMb) | < 0.01/< 0.01 | < 0.01/< 0.01 | – |
ANCOVA analysis of covariance, C chi-squared test, CI confidence interval, GLMM generalized linear mixed model, KW Kruskal–Wallis, logMAR logarithm of the minimal angle of resolution, LS least squares, NH natural history, SD standard deviation
aMixed-model ANCOVA with repeated measures taking into account the inter-eye correlation of each patient
bGLMM with repeated measures taking into account the inter-eye correlation of each patient