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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Cancer Cytopathol. 2022 Aug 30;131(1):37–49. doi: 10.1002/cncy.22637

Table 4.

Cellular details in cytologic specimens of intraductal papillary neoplasm of the bile duct

Case Cell Type N:C Ratio Cytoplasm Nucleus
Columnar Tall Columnar Cuboidal Volume Texture Intracytoplasmic Mucin Size Pseudo-stratification Anisonucleosis Membrane Chromatin Nucleoli Mitosis/Apoptosis
1 Present Present Absent Low Moderate Vacuolated Occasional Enlarged Absent Absent Smooth angulated Fine granular Inconspicuous −/−
2 Present Present Absent Low Moderate Vacuolated Present Enlarged Present Absent Smooth angulated Fine granular Conspicuous −/−
3 Present Absent Present Focally high Moderate Vacuolated Occasional Enlarged Absent Present Angulated Fine granular Conspicuous −/−
4 Present Absent Present Focally high Moderate Vacuolated Present Enlarged Present Present Angulated Fine granular Conspicuous −/−
5 Present Absent Present Focally high Moderate Vacuolated Occasional Enlarged Absent Absent Smooth Fine granular Inconspicuous −/−
6 Present Absent Present Focally high Scant Vacuolated Occasional Enlarged Absent Present Angulated Fine granular Conspicuous −/−
7 Absent Absent Present Focally high Moderate to abundant Vacuolated Occasional Enlarged Absent Present Smooth angulated Coarse Inconspicuous −/−
8 Present Absent Present Focally high Moderate Vacuolated Occasional Enlarged Absent Present Smooth angulated Fine granular Inconspicuous −/−
9 Present Absent Present Focally high Moderate to abundant Vacuolated Occasional Enlarged Absent Present Smooth angulated Fine granular Inconspicuous −/−
10 Present Present Present High Moderate Vacuolated Absent Enlarged Present Present Angulated Fine granular Conspicuous +/−
11 Absent Absent Present High Scant to Moderate Vacuolated Absent Enlarged Absent Absent Angulated Fine granular Inconspicuous −/−
12 Present Absent Present High Moderate Delicate Absent Enlarged Present Present Smooth angulated Fine granular Inconspicuous −/−
13 Present Present Absent High Moderate Vacuolated Absent Enlarged Present Present Smooth angulated Fine granular Inconspicuous +/+

Cases 1–2: intraductal papillary neoplasm of the bile duct with low-grade dysplasia; cases 3–5; intraductal papillary neoplasm of the bile duct with high-grade dysplasia; cases 6–9: intraductal papillary neoplasm of the bile duct with associated adenocarcinoma; cases 10–13: intraductal tubulopapillary neoplasm. N:C ratio: nuclear to cytoplasmic ratio.