FIG. 3.
Adoptive transfer of UreA-specific CD4+ T cells is therapeutically effective. T cells were transferred to recipients (UreA recipient) 10 weeks postinfection. Levels of colonization were assessed by quantitative culture (A) and by urease activity (B) at different time points after transfer. Results are expressed as the mean of five mice ± standard deviation. Statistically significant differences were calculated for nonrecipient and UreA recipient mice for each time point. The numbers of CFU were significantly different at weeks 7 (P < 0.05, one-tailed t test; P = 0.06, two-tailed t test) and 14 (P < 0.05, one-tailed t test; P = 0.08, two-tailed t test) posttransfer. Urease activities were significantly different (P < 0.05, one- and two-tailed t tests) at week 14.