TABLE 2.
Ability of Hib porin to provoke meningeal inflammation after 24 h of treatmenta
| Inoculant | Dose | Leukocyte countb | Protein contentc | Brain edemad |
|---|---|---|---|---|
| PBS | 7 μl | 40 ± 5 | 2.5 ± 0.5 | 75 ± 1.2 |
| Hib LPS | 1 μg | 350 ± 120* | 101 ± 7* | 77 ± 1.4** |
| Hib LPS plus PB | 1 μg + 1 μg | 36 ± 5 | 3.0 ± 0.5 | 75 ± 1.2 |
| Hib porin | 5 μg | 378 ± 130* | 98.0 ± 7.0* | 78 ± 1.5** |
| Hib porin plus PB | 5 μg + 5 ng | 395 ± 140* | 94.0 ± 7.0* | 78 ± 1.6** |
| PB | 1 μg | 45 ± 5 | 2.8 ± 0.5 | 75 ± 1.2 |
| BSA | 5 μg | 50 ± 5 | 2.7 ± 0.5 | 75 ± 1.1 |
a
All results are the means ± standard errors of three separate experiments with five animals each. ∗, P < 0.001; ∗∗, P < 0.5.
b
Leukocyte counts are expressed as cells per microliter of CSF.
c
Protein content is expressed as milligrams of protein per 100 ml of CSF.
d
Brain edema is expressed as grams of H2O/100 g of brain dry weight at 24 h.