Figure S4. Co-occurrence probability analysis of periportal and pericentral hepatocytes and endothelial cells.
(A, B, C, D) Co-occurrence probability ratio of (A) pericentral endothelial cells, (B) pericentral hepatocytes, (C) periportal endothelial cells, and (D) periportal hepatocytes with other periportal or pericentral endothelial cells or hepatocytes. Cell type abbreviations are as follows: “PP-hep,” “periportal hepatocyte”; “PC-hep,” “pericentral hepatocyte”; “PP-EC,” “periportal endothelial cell”; “PC-EC,” “pericentral endothelial cell.” (A, B) For small length scales (<500 μm), pericentral endothelial cells and hepatocytes tend to co-localize with each other with R > 1 (A, B). (C, D) This also holds true for periportal endothelial cells and hepatocytes (C, D). In contrast, periportal and pericentral cells do not co-localize, with R < 1. At larger length scales (>500 μm), the co-occurrence probabilities trend to R = 1, indicating no strong co-localization effects.