FIG. 2.
Alignment of PspC. The amino acid sequences which included the α-helical region and the proline-rich region of PspC were aligned with Mac Vector 6.5. The direct repeats within the α helix, the non-coiled-coil block, and the proline-rich region are indicated with arrows. Conserved regions are shaded, and gaps are shown with a dash. Entries are named for the strain from which the gene was cloned, with the exception of GenBank entries: SpsA1 (Y10818) from strain ATCC 33400 (serotype 1), SpsA2 (AJ002054) from strain ATCC 11733 (serotype 2), SpsA47 (AJ002055) from strain NCTC10319 (serotype 47), CbpA (AF019904) from strain LM91 (serotype 2), PbcA (a C3-binding protein) (AF067128), and TIGR sequence for a serotype 4 clinical isolate (30a). The capsular serotypes of the other strains are as follows: EF6796, 6A; BG8090, 19; L81905, 4; DBL6A, 6A; BG9163, 6B; D39, 2; and E134, 23.