Fig. 5.
Humoral responses to HEV-C1 infection.
(A) Anti-HEV antibody responses of individual IC, LD regimen-treated, and HD regimen-treated rats infected with CCY and SRN strains at 0, 14, and 28 days post infection assessed using HEV-C1 p241 species-specific immunoblot. P represents positive control using an anti-His antibody, whereas N represents negative control using uninfected rat sera. (B) Anti-HEV antibody responses of IC, LD regimen-treated, and HD regimen-treated rats at 0, 7, 14, and 28 days post infection assessed using the Wantai HEV IgG assay. Data of SRN and CCY strain-infected animals in each group are pooled together. Bars represent mean and SEM. HD, high dose; HEV-C1, HEV-C genotype 1; IC, immunocompetent; LD, low dose.