Figure 2.
Structure and masses of different antigen binders. (A) Monoclonal antibody, (B) Single-chain variable fragment (scFv) is a fusion protein of the variable regions of the heavy (VH) and light chains (VL), connected with a short linker. (C) Affibodies are small proteins composed of a three-helix bundle based on the scaffold of one of the IgG-binding domains of Protein. They are generally constructed by combinatorial randomization of 13 amino acid positions in helices one and two. (D) Single-Domain Antibody are the variable parts from heavy chain only antibodies that are naturally present in Camelidae and consist of 3 complementarity-determining regions (CDR) and 4 framework regions (FR).