Table 2.
Advantages and challenges of using exosomes in therapeutic drug delivery systems.
| Advantages | Challenges |
|---|---|
| Nanoscopic size | A large-scale purification method for clinical use is still missing |
| Low immunogenicity | Efficient cargo loading methods without damaging EV integrity are lacking |
| High biocompatibility | The exact mechanism of interaction between exosomes and targeted cells needs elucidation |
| Encapsulation of various cargos | In vivo data yet less studied |
| The ability to overcome biological barriers | Clinical translation for therapeutic delivery is lacking |