TABLE 2.
Effects of azithromycin, rifampin, and the combination of azithromycin and rifampin on chlamydial infectivitya
| Day postinfection | Infectivity (% IFU/105 cells) after treatment with:
|
||
|---|---|---|---|
| AZM (0.5 μg/ml) | RIF (0.015 μg/ml) | AZM (0.5 μg/ml) + RIF (0.015 μg/ml) | |
| 2 | 100 | 100 | 100 |
| 4 | 22.8 ± 3.2 | 12.9 ± 2.2 | 23.9 ± 3.3 |
| 8 | 0.009 ± 0.006 | 0.003 ± 0.001 | 0 |
| 14 | 0 | 0 | 0 |
a
Treatment with 0.5 μg of azithromycin (AZM) per ml or 0.015 μg of rifampin (RIF) per ml, in both, was started 2 days after infection. Culture of cells without antibiotics resulted in complete destruction of the cell monolayer in 6 days. The data are the means ± standard deviations of four experiments.