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Mutational distribution in JH intron sequences. (A) Black vertical lines represent the number of mutations/bp x 102 (y-axis) for each residue from VDJ clones utilizing JH1, JH2, JH3, and JH4 genes. X-axis depicts the distance from JH1 to Eμ (B) Triangles indicate the position of WRCH (blue) and WGCW (red) motifs relative to the JH genes (squares). Half circle shows the portion of the Eμ intronic enhancer that was sequenced.
