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. 2022 Apr 6;13:850226. doi: 10.3389/fimmu.2022.850226

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Copyright © 2022 Kollis, Ebert, Toubia, Bastow, Ormsby, Poonnoose, Lenin, Tea, Pitson, Gomez, Brown and Gargett

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCR2⁺, CCR5⁺, CXCR3⁺ and CXCR6⁺ CD4⁺ T-cell populations are significantly enriched in patient glioblastoma compared to peripheral blood. (A) Representative histograms showing chemokine receptor expression within CD4⁺ T-cell subsets in glioblastoma (GBM) (coloured) and naïve CD4⁺ T cells in matched blood samples (grey). Also see Supplementary Figure 4 for additional blood CD4⁺ T-cell subsets. Representative of matched blood and GBM samples n=5-8 each. (B–I) Proportions of CD4⁺ T-cell subsets in blood and matched GBM biopsies expressing (B) CCR2, (C) CCR4, (D) CCR5, (E) CCR6, (F) CXCR3, (G) CXCR4, (H) CXCR6 and (I) CX3CR1. Each dot represents one patient, lines represent paired patient sample. Two-tailed paired Student’s t test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, nd=not detected.