Figure 6. OHT mice exhibited a largely normal circadian re-entrainment behavior.
(a) Examples of double plot actograms for a wt control and a bilaterally lasered mouse (OHT) under bright light intensity (a) or low light intensity (c) during light portion of the light: dark cycle. Six-hour phase-advance was performed to assess re-entrainment. White and light gray backgrounds indicate the light portions, and the dark gray backgrounds indicate the dark portions of the light: dark cycle, respectively. Red arrows point to the day when re-entrainment was observed. Black arrows point to the light shift. (b, d) Quantification of the average days it took for mice to re-entrain to the new light: dark cycle after phase-advance. (e) Examples of double plot actograms of circadian free run under constant darkness (DD) after day 105. Red asterisks mark the onset of activity on each day. (f) The average free running circadian periods for control and OHT mice. NS: Not significant; *: P < 0.05 in Mann-Whitney test. Data presented as Mean ± SEM.