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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Comp Neurol. 2022 Jan 20;530(9):1494–1506. doi: 10.1002/cne.25293

Figure 4. M4 ipRGC suffered significant loss following the chronic IOP elevation.

Figure 4.

(a) Confocal images of flat mounted retinas from a control eye and an OHT eye eight-months post laser surgery immunostained with melanopsin and SMI-32 antibodies. White crosses denote melanopsin-positive cells and violet crosses denote large cells positive for both melanopsin and SMI-32. Scale bar is 20 μm. (b) Quantification of M4 cell density in control and OHT retinas. (c) Contrast sensitivity measured at 0.103 and 0.192 cycle per degree (c/d) of control and OHT group eight-months post laser surgery. **: P < 0.01; ***: P < 0.001 in Mann-Whitney test. Data presented as Mean ± SEM.