FIG. 3.
Time of appearance of NNRTI resistance mutations relative to rebound in plasma virus load in study DMP 266-004 patients for whom efavirenz combination therapy failed. (A) Time of appearance of single NNRTI resistance mutations and multiple, linked NNRTI resistance mutations. The cumulative percentage of patients with sequence data available and with linked NNRTI mutations in one or more cloned viral genomes in study DMP 266-004 is plotted as a function of the interval before or after the initial rebound in viral load which defined the treatment failure day. (B) Time of appearance of specific efavirenz-selected NNRTI resistance mutations. The cumulative percentage of patients with sequence data available and with specific NNRTI mutations in one or more cloned viral genomes in study DMP 266-004 is plotted as a function of the interval before or after the initial rebound in viral load which defined the treatment failure day. Linkage of mutations is not considered.