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. 2022 Mar 28;52:102305. doi: 10.1016/j.redox.2022.102305

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© 2022 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Activation of XBP1-mediated hepatocellular mitophagy and pyroptosis and macrophage STING signaling pathway in patients with ALI.

Human liver tissues were collected from five patients with ALI and five controls. (A) IHC XBP1s-stained liver tissue sections. Scale bar, 50 $μm$ . Immunofluorescence staining of liver tissue sections from each group. Albumin (pink), LC3 (red), cleaved caspase-1 (green), GSDMD-NT (yellow), and DAPI (blue). Scale bar, 50 $μm$ (B) and CD68 (yellow), cGAS (red), STING (pink), P-TBK1 (green) and DAPI (blue). Scale bar, 50 $μm$ (C). Data are presented as the mean $\pm$ SEM (n = 5). *P $< 0.05$ , **P $< 0.01$ , ***P $< 0.001$ . NS, not significant; IHC, immunohistochemistry. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)