TABLE 1.
Analysis of randomly selected mutant plasmids conferring increased resistance to cefoxitin (MIC, >48 μg/ml) derived from strain LB4(pSHA2)
| Plasmid | Type of mutation | IS positiona |
|---|---|---|
| pSHA119 | Point mutation or small deletion | |
| pSHA124 | Point mutation or small deletion | |
| pSHA125 | Point mutation or small deletion | |
| pSHA128 | Insertion of IS1 | 87 |
| pSHA123 | Insertion of IS903 | 8 |
| pSHA103 | Insertion of IS5 | −4 |
| pSHA100 | Insertion of IS26 | 14 |
| pSHA146 | Insertion of IS1 | 95 |
| pSHA149 | Insertion of IS5 | 7 |
| pSHA151 | Insertion of IS5 | 29 |
| pSHA101 | Insertion of IS26 | 77 |
| pSHA154 | Insertion of IS903 | 28 |
| pSHA157 | Deletion | |
| pSHA104 | Deletion |
a
Values indicate the positions (in base pairs) of the ISs with respect to the ompK36 start codon.