TABLE 3.
Tumor-derived EVs as biomarkers in cancer diagnosis and treatment.
| Cargoes | Cancer types | Source of EVs | Applications | References |
|---|---|---|---|---|
| Let-7a, miR-99b, miR-146a, miR-155, miR-191, miR-1246 | Acute myeloid leukemia | Serum | Diagnosis | Hornick et al. (2015) |
| Circular RNA SETDB1, miR-31-5p | Lung adenocarcinoma | Serum/plasma | Diagnosis | Xu et al. (2021), Yu et al. (2021) |
| ZFAS1, miR-301a-3p | Gastric cancer | Serum | Diagnosis | Pan et al. (2017), Xia et al. (2020) |
| GPC1 | Pancreatic cancer | Serum | Diagnosis | Melo et al. (2015) |
| Contactin-1 | Melanoma cancer | Plasma | Diagnosis | Pietrowska et al. (2021) |
| Let-7p-3b, miR-150-3p, miR-145-3p, miR-139-3p | Colon cancer | Plasma | Diagnosis | Min et al. (2019) |
| miR-92a-3p | HCC | Plasma | Diagnosis | Xia et al. (2020) |
| LncHILAR | Renal cancer | Plasma | Diagnosis | Hu et al. (2021) |
| miR-21 | Breast cancer | Serum | Diagnosis | Yuan et al. (2021) |
| HMGB3 | Nasopharyngeal carcinoma | Serum | Diagnosis | Zhang et al. (2021a) |
| TrpC5 | Breast cancer | Peripheral blood | Therapy monitoring | Ma et al. (2014) |
| Annexin A6 | Triple-negative breast cancer | Serum | Therapy monitoring | Li et al. (2021) |
| miR-208b, miR-21-5p | Colorectal cancer | Serum | Therapy monitoring | Ning et al. (2021), He et al. (2021) |
| S100A4, osteopontin | HCC | Plasma | Prognosis | Sun et al. (2021) |
| LncRNA-SOX2OT | NSCLC | Peripheral blood | Prognosis | Ni et al. (2021) |