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. 2021 Dec 15;7(51):eabi7629. doi: 10.1126/sciadv.abi7629

Fig. 4. Dual-AAV delivery restores DPOAE and ABR thresholds 4 weeks after injection.

Fig. 4.

(A) Representative Fourier analysis of DPOAE waveforms revealed two frequency components at the stimulus frequencies f1 (13.3 kHz) and f2 (16 kHz) and a distortion product at the predicted frequency 2f1 − f2 (10.6 kHz) in a WT mouse cochlea (top trace). Traces below show the distortion product for sound pressure levels from 10 to 50 dB on an expanded frequency and amplitude scale for WT, StrcΔ/Δ, and dual vector–injected StrcΔ/Δ cochleas. The bold traces indicate the DPOAE threshold. (B) DPOAE thresholds as a function of (f2) stimulus frequency for WT (black) and dual vector−injected StrcΔ/Δ mice with (light green) and without (red) recovery. Red and light green lines represent data from individuals. Mean ± SE are shown for WT (black), 20 dual vector–injected StrcΔ/Δ mice with recovery (green), and the five best recoveries (purple). (C) Families of ABR traces recorded from WT, StrcΔ/Δ, and dual vector–injected StrcΔ/Δ cochleas, evoked by sound pressure levels between 25 and 110 dB. Bold traces indicate ABR thresholds. (D) ABR thresholds plotted as a function of stimulus frequency for WT (black) and dual vector–injected StrcΔ/Δ mice with (light green) and without (red) recovery. Light green lines represent data from individuals. Mean ± SE are shown for WT (black), 20 dual vector–injected StrcΔ/Δ mice with (green) and 20 without (red) recovery, and the five StrcΔ/Δ mice with the best recoveries (purple).