Figure 5 ∣. Delineation of CRE modules across 222 fetal and adult human cell types.
A) Heatmap representation of chromatin accessibility for 1,154,611 cCREs across 222 fetal and adult cell types. Color represents normalized chromatin accessibility. cCREs were organized into 150 modules by K-means clustering, indicated by the color bars on the right. 20 groups of lineage-specific modules (colored boxes) are highlighted. B-D) Heatmaps showing chromatin accessibility (B), GO terms (C) and motifs (D) with maximal enrichment in a subset of CRE modules (rows) for immune cell types. The GO and motif heatmaps are colored by enrichment −log10P. Only the most enriched TF motif in each of the previously identified motif archetypes (Vierstra et al., 2020) was selected as the representative and the top 5 motifs were selected for each module. Full GO and motif enrichments are available on Mendeley Data: 10.17632/yv4fzv6cnm.1.