Figure 3 ∣. Integrative analysis of adult and fetal single-cell chromatin accessibility atlases.
A) Number of sci-ATAC-seq cells per tissue type for 30 adult and 15 human fetal tissue types that were integrated. Matching tissue types between adult and fetal datasets are highlighted in red or blue respectively. Standard: sentinel tissue (trisomy 18 cerebrum). B) UMAP embedding of 1,323,041 nuclei from fetal and adult tissues. Each dot in the scatter plot represents a nucleus, colored by life stage. C) Heatmap showing Pearson correlation coefficient (PCC) between 69 adult cell types and 89 fetal cell types from 17 manually defined cell groups that are present in both adult and fetal tissues. A comprehensive heatmap is provided in Figure S5. D) Bar plot showing the median PCC for each major cell group indicated in C.