Figure 1 ∣. Single-cell chromatin accessibility analysis of 30 adult human primary tissues.
A) A total of 92 biosamples from 30 tissue types, were used for sci-ATAC-seq. The number of nuclei profiled per tissue is denoted in parentheses. B) Clustering of 615,998 nuclei revealed 30 major cell groups. Each dot represents a nucleus colored by cluster ID. Embedding was created by Uniform Manifold Approximation and Projection (UMAP) (McInnes et al., 2018). C) An example illustrating subclusters within the major cell group of gastrointestinal (GI) epithelial cells revealed by iterative clustering. D) Bar plot showing the number of cell types identified in each of the 30 human tissues, counting only cell types constituting >0.2% of all cells in the given tissue. E) Distribution of cell types across human tissues. The dendrogram on the left was created by hierarchical clustering of cell clusters based on chromatin accessibility. The bar chart represents relative contributions of tissues to cell clusters. Raw data are available on Mendeley Data: 10.17632/yv4fzv6cnm.1.