Table 5.
Compliance with individual Landis 4 items, in vivo and in vitro research
| Item | NPG before | NPG after | Adj p | Non-NPG before | Non-NPG after | Adj p | ||||||||||||
| n | N | % | CI | n | N | % | CI | n | N | % | CI | n | N | % | CI | |||
| In vivo | ||||||||||||||||||
| Report method of randomisation? | 3 | 170 | 1.8 | 0.6 to 5.3 | 19 | 170 | 11.2 | 7.2 to 16.9 | NS | 1 | 134 | 0.8 | 0.1 to 5.1 | 4 | 149 | 2.7 | 1.0 to 6.9 | NS |
| Statement about randomisation | 14 | 169 | 8.3 | 5.0 to 13.5 | 97 | 151 | 64.2 | 56.3 to 71.5 | 3×10–14 | 7 | 136 | 5.1 | 2.5 to 10.4 | 14 | 147 | 9.5 | 5.6 to 15.4 | NS |
| Blinded? | 8 | 198 | 4.0 | 2.0 to 7.9 | 42 | 184 | 22.8 | 17.3 to 29.4 | 8×10–6 | 2 | 162 | 1.2 | 0.3 to 4.8 | 7 | 183 | 3.8 | 1.8 to 7.8 | NS |
| Statement about blinding | 3 | 182 | 1.6 | 0.5 to 5.0 | 73 | 132 | 55.3 | 46.8 to 63.4 | 3×10–14 | 1 | 151 | 0.7 | 0 to 4.6 | 2 | 165 | 1.2 | 0 to 4.7 | NS |
| Exclusions reported? | 28 | 202 | 13.9 | 9.7 to 19.3 | 58 | 189 | 30.7 | 24.5 to 37.6 | 0.008 | 16 | 164 | 9.8 | 6.1 to 15.3 | 22 | 189 | 11.6 | 7.8 to 17.0 | NS |
| Exclusion criteria defined? | 24 | 200 | 12 | 8.2 to 17.3 | 35 | 188 | 18.6 | 13.7 to 24.8 | NS | 14 | 163 | 8.6 | 5.2 to 14.0 | 20 | 188 | 10.6 | 7.0 to 15.9 | NS |
| Clear these were prespecified? | 1 | 25 | 4 | 0.6 to 23.6 | 5 | 39 | 12.8 | 5.4 to 27.3 | NS | 0 | 17 | 0 | 0.0 to 22.9 | 0 | 21 | 0 | 0.0 to 19.2 | NS |
| Was SSC done? | 4 | 196 | 2.0 | 0.8 to 5.3 | 27 | 182 | 14.8 | 10.4 to 20.8 | 0.0008 | 0 | 156 | 0 | 0.0 to 3.0 | 3 | 183 | 1.6 | 0.5 to 5.0 | NS |
| If not done, was SSC mentioned? | 3 | 192 | 1.6 | 0.5 to 4.7 | 90 | 154 | 58.4 | 50.5 to 66.0 | 3×10–14 | 1 | 157 | 0.6 | 0 to 4.4 | 2 | 180 | 1.1 | 0.3 to 4.3 | NS |
| In vitro | ||||||||||||||||||
| Report method of randomisation? | 0 | 149 | 0 | 0.0 to 3.1 | 5 | 173 | 2.9 | 1.2 to 6.8 | NS | 1 | 125 | 0.8 | 0.1 to 5.5 | 1 | 157 | 0.6 | 0.1 to 4.4 | NS |
| Statement about randomisation | 0 | 149 | 0 | 0.0 to 3.1 | 26 | 167 | 15.6 | 10.8 to 21.9 | 7×10–5 | 0 | 123 | 0 | 0.0 to 3.8 | 4 | 156 | 2.6 | 1.0 to 6.6 | NS |
| Blinded? | 6 | 155 | 3.9 | 1.8 to 8.4 | 16 | 179 | 8.9 | 5.6 to 14.1 | NS | 3 | 131 | 2.3 | 0.7 to 6.9 | 1 | 162 | 0.6 | 0.1 to 4.2 | NS |
| Statement about blinding | 1 | 150 | 0.7 | 0.1 to 4.6 | 25 | 157 | 15.9 | 11.0 to 22.5 | 0.0002 | 0 | 127 | 0 | 0.0 to 3.7 | 1 | 158 | 0.6 | 0.1 to 4.3 | NS |
| Exclusions reported? | 13 | 159 | 8.2 | 4.8 to 13.6 | 29 | 182 | 15.9 | 11.3 to 22.0 | NS | 7 | 133 | 5.3 | 2.5 to 10.6 | 10 | 165 | 6.1 | 3.3 to 10.9 | NS |
| Exclusion criteria defined? | 12 | 159 | 7.5 | 4.3 to 12.8 | 23 | 178 | 12.9 | 8.7 to 18.7 | NS | 7 | 133 | 5.3 | 2.5 to 10.6 | 9 | 165 | 5.5 | 2.9 to 10.2 | NS |
| Clear these were prespecified? | 0 | 14 | 0 | 0.0 to 26.8 | 1 | 24 | 4.2 | 0.6 to 24.4 | NS | 0 | 8 | 0 | 0.0 to 40.0 | 0 | 11 | 0 | 0.0 to 32.1 | NT |
| Was SSC done? | 2 | 155 | 1.3 | 0.3 to 5.0 | 14 | 177 | 7.9 | 5.1 to 13.5 | NS | 0 | 129 | 0 | 0.0 to 3.6 | 0 | 161 | 0 | 0.0 to 2.9 | NS |
| If not done, was Sample Size Calculation mentioned? | 5 | 153 | 3.3 | 1.4 to 7.6 | 47 | 165 | 28.5 | 22.1 to 35.8 | 2×10–7 | 0 | 129 | 0 | 0.0 to 3.6 | 1 | 162 | 0.6 | 0.1 to 4.2 | NS |
n, number meeting the criteria; N, total number of studies where that criteria is relevant; %, per cent meeting the criteria; CI, 95% CI of that percentage: Adj p, adjusted significance level (two-sample proportion test (prop.test) followed by Holm-Bonferroni correction (p.adjust.methods)); NS, not significant at p<0.05: NT, not tested (n<10 for one of the comparisons).
NPG, Nature Publishing Group.