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Model showing that REA and SRC-1 compete for binding to the ER and that PTα recruits REA away from ER, antagonizing the repressive activity of REA and enabling PTα to enhance ER transactivation activity. REA blocks coactivator SRC-1 binding and PTα acts in competition with REA to regulate transcriptional effectiveness, interfering with REA binding to ER. Therefore, by acting as an inhibitor of an anticoactivator (REA), PTα acts to enhance transcriptional activity of the liganded ER.
