Fig. 3.
Aconitase reaction mechanism. The isomerization reaction of citrate (shown in blue) to cis-Aconitate (magenta) is facilitated by the [4Fe–4S] cluster found within aconitase (shown in red). The addition of another labile iron (Feα) transforms inactive aconitase into its active form, and coordinates with water molecules and oxygen atoms of citrate to facilitate enzyme catalysis. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)