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Crystal structures of WCK 4234, zidebactam, and avibactam bound to P. aeruginosa PBP3. (A, C, and E) Electron difference density for WCK 4234, zidebactam, and avibactam, respectively, contoured at 2.75 σ level. (B, D, and F) Interactions of DBO ligands in the active site of PBP3 for WCK 4234, zidebactam, and avibactam, respectively.
