Figure 3.
Mediation Models for AEA and 2-AG. Mediation model for AEA (A) along with corresponding histogram of bootstrapped indirect effects and 95% CI (B) indicated that circulating concentrations of AEA mediated the relationship between aerobic exercise and reduced threat expectancy ratings following reinstatement. Mediation model for 2-AG (C), along with corresponding histogram of bootstrapped indirect effects and 95% CI (D) indicated that circulating concentrations of 2-AG did not mediate the relationship between aerobic exercise and reduced threat expectancy ratings following reinstatement. Values listed are standardized regression coefficients for path a (effect of independent variable on biomarker variable), path b (effect of biomarker variable on dependent variable), the indirect effect (product of regression coefficients for predictor variables in path a and b), path c (effect of independent variable on dependent variable without biomarker variable included in model), and path c’ (difference between direct and indirect effect). 95% CI for the indirect effect (used to determine if mediation occurred; denoted * for 95% CIs not containing zero) was obtained from bootstrap procedure involving resampling with replacement and 10,000 iterations.