Figure 5.
Neurofilament light (NFL) levels are correlated with blood–brain barrier disruption post traumatic brain injury. Correlation analysis was performed between the concentration of NFL, neuron-specific enolase (NSE), S100 beta (S100B) and claudin-5 3 hours post-traumatic brain injury (TBI). Four treatment groups were used: saline–sham (SS), ethanol–sham (ES), saline–TBI (ST) and ethanol–TBI (ET). (a) Correlation of NFL and claudin-5 levels were significant in the SS group (p = 0.0480). (b) Correlation of NFL and claudin-5 were significant in the ST group (p = 0.0191). The other treatment groups (ES and ET) did not show this correlation. (ES: p = 0.1469; ET: R2 = 0.0136; p = 0.6785). Overall slope comparison revealed significant differences in the treatment groups between NFL and claudin-5 (F = 3.157; p = 0.0320). Post hoc analysis revealed a significant difference in the slopes between the ST and ET group (p = 0.0303). Correlation with linear regression is shown. Group sizes: SS, n = 8; ES, n = 14; ST, n = 24; ET, n = 17. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001