Table 2.
The mainly potential drugs identified by L1000FWD database.
| Rank | Drug | Similarity Score | p-value | q-value | Z-score | Combined Score | MOA |
|---|---|---|---|---|---|---|---|
| 1 | SIB-1893 | -0.0763 | 4.29E-20 | 2.59E-17 | 1.67 | -32.29 | glutamate receptor antagonist |
| 2 | geldanamycin | -0.0671 | 2.45E-16 | 7.08E-14 | 1.62 | -25.31 | HSP inhibitor |
| 3 | PD-184352 | -0.0624 | 4.33E-15 | 9.56E-13 | 1.75 | -25.2 | MEK inhibitor |
| 4 | PF-04217903 | -0.0509 | 3.27E-09 | 0.000000191 | 1.77 | -15.06 | c-Met inhibitor |
| 5 | PD-0325901 | -0.0509 | 2.55E-09 | 0.000000154 | 1.68 | -14.47 | MEK inhibitor |
| 6 | FCCP | -0.0486 | 0.000000042 | 0.00000183 | 1.64 | -12.06 | Unknown |
| 7 | PD-198306 | -0.0474 | 3.88E-08 | 0.00000171 | 1.68 | -12.42 | MAP kinase inhibitor, MEK inhibitor |
| 8 | BI-2536 | -0.0474 | 0,000000161 | 0.00000612 | 1.74 | -11.84 | PLK inhibitor |
| 9 | PAROXETINE | -0.0462 | 0,000000554 | 0.0000179 | 1.63 | -10.21 | selective serotonin reuptake inhibitor (SSRI) |
| 10 | BRD-A66861218 | -0.0462 | 0,000000199 | 0.00000733 | 1.76 | -11.82 | anti-inflammatory agent |