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. 2021 Mar 15;5(9):1226–1239. doi: 10.1038/s41562-021-01069-w

Table 1.

Genomic loci associated with brain asymmetries on multivariate analysis. All lead SNPs are shown

Genomic locus Lead SNP Position Functional category Effect allele Effect allele frequency mvGWAS r value mvGWAS P value Nearest gene Central asymmetry indexesa
1 rs6658111 1p33 Intergenic G 0.37 0.0631 9.75 × 10−11 AL356458.1 Parahippocampal (SA), superior frontal (SA), parahippocampal (CT)
2 rs62130503 2p23.3 NcRNA_intronicb T 0.05 0.0630 1.22 × 10−10 MAPRE3 Thalamus (SUB), parahippocampal (SA)
2 rs12617392 2p23.3 Intronic A 0.44 0.0638 4.02 × 10−11 CGREF1 Inferior temporal (SA), caudal anterior cingulate (SA), isthmus of cingulate (SA)
3 rs368536282c 2q34 Intergenic T 0.03 0.0631 1.07 × 10−10 MAP2 Superior frontal (SA), accumbens (SUB), posterior cingulate (CT)
4 rs2279829 3q24 3′ UTRd T 0.22 0.0613 1.26 × 10−9 ZIC4 Isthmus of cingulate (CT), precuneus (SA), posterior cingulate (CT), fusiform (SA)
5 rs9307052c 4q22.1 Intronic T 0.11 0.0591 2.27 × 10−8 FAM13A Rostral anterior cingulate (CT), posterior cingulate (CT), medial orbitofrontal (SA)
6 rs869219775 5q15 Intergenic T 0.14 0.0606 3.06 × 10−9 NR2F1 Inferior parietal (SA), transverse temporal (SA)
7 rs7781 6p21.33 Downstream G 0.24 0.0628 1.62 × 10−10 TUBB Isthmus of cingulate (CT), rostral anterior cingulate (CT), pars triangularis (SA)
8 rs9385385 6q22.31 ncRNA_intronicb T 0.45 0.0595 1.37 × 10−8 NCOA7 Posterior cingulate (CT), pericalcarine (SA)
9 rs6947352 7p14.3 Intronic A 0.31 0.0585 4.38 × 10−8 BBS9 Banks of the superior temporal sulcus (SA)
10 rs911934 9q22.33 Intergenic G 0.70 0.0699 2.39 × 10−15 GALNT12 Inferior parietal (SA), isthmus of cingulate (SA), precuneus (SA), paracentral (SA), supramarginal (SA), entorhinal (CT)
11 rs41298373 10p14 Exonic A 0.10 0.0940 4.75 × 10−38 ITIH5 Superior temporal (SA), parahippocampal (SA), fusiform (SA), inferior temporal (CT), transverse temporal (SA)
12 rs10783306c 12q13.12 Intergenic C 0.33 0.0647 9.99 × 10−12 TUBA1B Superior frontal (SA), entorhinal (SA), medial orbitofrontal (SA), pars triangularis (SA)
13 rs160459 14q23.1 Intergenic C 0.46 0.0652 4.98 × 10−12 DACT1 Banks of the superior temporal sulcus (SA), transverse temporal (SA), pericalcarine (SA)
14 rs201816193 14q23.1 Intergenic G 0.12 0.0621 4.38 × 10−10 DAAM1 Isthmus of cingulate (SA), cuneus (SA)
15 rs72813426 16q24.3 Intronic G 0.24 0.0685 2.45 × 10−14 SPIRE2 Paracentral (SA), isthmus of cingulate (SA), middle temporal (SA)
15 rs111398992c 16q24.3 Intronic T 0.13 0.0694 5.99 × 10−15 TUBB3 Isthmus of cingulate (CT), fusiform (SA), rostral anterior cingulate (CT), pericalcarine (SA)
16 rs55938136 17q21.31 NcRNA_intronicb G 0.22 0.0695 4.91 × 10−15 CRHR1 Parahippocampal (SA), middle temporal (SA), pallidum (SUB), hippocampus (SUB), pars triangularis (SA)
16 rs35908989 17q21.31 Intronic C 0.23 0.0595 1.34 × 10−8 MAPT Supramarginal (SA), caudate (SUB)
16 rs35853889 17q21.31 3′ UTRd TG 0.19 0.0765 1.43 × 10−20 MAPT Rostral anterior cingulate (CT), cuneus (SA), isthmus of cingulate (SA), parahippocampal (SA), rostral anterior cingulate (SA), parahippocampal (CT)
16 rs80103986c 17q21.31 Intronic T 0.20 0.0708 5.16 × 10−16 KANSL1 Parahippocampal (SA), middle temporal (SA), pallidum (SUB), hippocampus (SUB), pars triangularis (SA)
16 rs568039055 17q21.31 3′ UTRd C 0.20 0.0692 7.87 × 10−15

LRRC37A2

ARL17A

 Parahippocampal (SA), isthmus of cingulate (SA), rostral anterior cingulate (CT), cuneus (SA)
17 rs11672092c 19p13.3 Intronic T 0.22 0.0619 5.69 × 10−10 TUBB4A Isthmus of cingulate (CT), lateral orbitofrontal (SA), middle temporal (SA)
18 rs6135555 20p12.1 Intronic A 0.39 0.0600 7.00 × 10−9 MACROD2 Pericalcarine (SA), caudate (SUB)
19 rs7283026 21q22.3 Intronic C 0.27 0.0616 8.42 × 10−10 COL18A1 Supramarginal (SA), transverse temporal (SA)
20 rs9615351 22q13.31 Exonic G 0.25 0.0588 3.02 × 10−8 CELSR1 Isthmus of cingulate (CT), transverse temporal (SA)
21 rs12400461 Xp22.33 Intergenic C 0.58 0.0595 1.24 × 10−8 ASS1P4 Inferior temporal (SA), pars opercularis (SA)

aCentral traits for each SNP are those asymmetry indexes that contribute to its multivariate association (Methods). SA, surface area; CT, cortical thickness; SUB, subcortical volume.

bIntronic to a gene for a non-coding RNA.

cLead variants are in high LD with handedness-associated variants.

dUntranslated region.