Figure 1.
eGFR distributions for guideline-recommended equations and proposed race-free modifications. (A) Density plots for reported values across eGFR equations. Equations recommended by Kidney Disease: Improving Global Outcomes (KDIGO) are marked with asterisks (*). Percentage labels indicate the proportion falling below the dotted line (eGFR=60), a threshold recommended by KDIGO as one component for the diagnosis of CKD. The sample comprises 861 Black subjects and 3573 White/Other subjects from the NHANES. Distributions and summary statistics were computed using the NHANES weights and survey structure to be representative of the 1999–2002 US population. (B) Summary statistics and proportions under relevant eGFR thresholds recommended by KDIGO for CKD diagnosis (eGFR<60 or urinary albumin-creatinine ratio >30 mg/g) and stage reclassification (eGFR<30, 45, or 60) of CKD. Median change is evaluated relative to eGFRcr-cys, the eGFR equation with the highest reported accuracy compared with measured GFR.