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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Lancet Oncol. 2021 Mar 4;22(4):e136–e172. doi: 10.1016/S1470-2045(20)30751-8

Table 5.

Economic costs and benefits among cancer cases diagnosed between 2020 and 2030 (11 modelled cancers) (all results discounted 3% annually)

Incremental cancer treatment
costs (2020-2030), $ billion
(95% uncertainty interval)
Lifetime return on investment: Full Income [2.3x GDP], (95%
uncertainty interval)
Difference Percent
increase
Productivity gains, $
billion
Net benefit, $ billion Return per $
invested
Global
Imaging only 6.84 (1.77-15.86) 0.2% (0.1-0.3) 1,226.21 (540.05-2,161.8) 1,219.37 (535.47-2,157.29) 179.19 (84.71-625.09)
Treatment only 50.72 (14.92-111.88) 1.5% (0.8-2.4) 1,183.24 (504.9-2,206.54) 1,132.51 (489.13-2,114.69) 23.33 (12.40-60.40)
Treatment + quality 225.50 (83.87-408.34) 6.7% (5.7-7.8) 1,386.07 (726.42-2,342.19) 1,160.56 (484.04-2,053.7) 6.15 (2.66-16.71)
Comprehensive 232.88 (85.92-421.97) 6.9% (6.0-8.0) 2,894.41 (1,794.55-4025.16) 2,661.54 (1,631.20-3,775.64) 12.43 (6.47-33.23)
Africa
Imaging only 0.46 (0.23-0.79) 1.9% (1.2-3.0) 27.38 (9.61-65.80) 26.93 (9.29-65.34) 59.97 (22.11-128.14)
Treatment only 6.85 (3.82-11.22) 29.4% (17.6-42.2) 120.97 (52.46-210.96) 114.12 (44.51-203.06) 17.67 (8.09-33.93)
Treatment + quality 11.14 (6.64-16.98) 47.8% (34.1-63.1) 164.86 (88.57-237.47) 153.72 (79.95-225.41) 14.80 (8.05-25.71)
Comprehensive 11.67 (7.01-17.70) 50.1% (36.2-66.4) 249.66 (187.61-303.31) 237.99 (177.71-291.8) 21.39 (14.15-34.34)
Asia
Imaging only 3.42 (0.66-9.37) 0.4% (0.1-0.6) 713.38 (86.71-1,616.35) 709.96 (86.03-1,610.45) 208.70 (77.77-850.18)
Treatment only 24.58 (4.35-69.42) 2.7% (0.5-6.2) 679.76 (107.85-1,681.10) 655.17 (103.01-1,621.55) 27.65 (12.89-68.97)
Treatment + quality 37.98 (13.16-86.15) 4.4% (1.9-8.5) 772.73 (182.13-1,686.61) 734.75 (164.77-1,613.12) 20.35 (8.10-49.52)
Comprehensive 41.59 (14.76-91.25) 4.7% (2.3-8.9) 1,653.82 (828.58-2,458.01) 1,612.22 (802.55-2,410.54) 39.76 (17.99-101.74)
Europe
Imaging only 1.95 (0.23-5.52) 0.2% (0.0-0.4) 281.15 (77.79-612.65) 279.20 (76.86-605.35) 144.32 (71.07-686.83)
Treatment only 14.73 (1.88-38.95) 1.2% (0.2-2.6) 257.18 (82.05-517.31) 242.45 (72.14-493.25) 17.46 (8.28-66.89)
Treatment + quality 171.39 (59.5-314.06) 14.5% (13.3-16.0) 301.80 (114.77-602.30) 130.41 (−119.56-444.47) 1.76 (0.49-6.02)
Comprehensive 173.59 (59.79-315.94) 14.7% (13.6-16.1) 618.57 (367.27-884.37) 444.98 (160.23-737.88) 3.56 (1.64-10.47)
Latin America and the Caribbean
Imaging only 0.52 (0.03-1.31) 0.6% (0.0-1.1) 138.85 (8.89-259.83) 138.33 (8.85-259.06) 266.38 (109.69-1,351.47)
Treatment only 2.21 (0.20-7.03) 2.9% (0.3-7.4) 79.99 (8.78-241.17) 77.79 (8.54-237.43) 36.28 (14.10-152.10)
Treatment + quality 2.56 (0.45-7.42) 3.4% (0.7-8.0) 87.66 (9.42-264.11) 85.10 (8.85-260.56) 34.27 (12.16-124.16)
Comprehensive 3.08 (0.61-8.04) 4.1% (1.3-8.7) 245.96 (123.82-403.20) 242.88 (122.20-397.69) 79.77 (30.36-384.86)
Northern America
Imaging only 0.37 (0.00-3.26) 0.0% (0.0-0.2) 47.48 (0.00-348.01) 47.12 (0.00-345.16) 128.94 (64.85-361.54)
Treatment only 1.22 (0.00-11.54) 0.1% (0.0-0.8) 24.24 (0.00-202.14) 23.02 (0.00-181.52) 19.83 (7.95-72.25)
Treatment + quality 1.22 (0.00-11.54) 0.1% (0.0-0.8) 32.60 (0.00-202.14) 31.37 (0.00-190.39) 26.66 (8.18-1,398.67)
Comprehensive 1.59 (0.00-11.58) 0.1% (0.0-0.8) 80.12 (0.00-373.7) 78.53 (0.00-371.43) 50.36 (8.42-984.28)
Oceania
Imaging only 0.13 (0.00-0.59) 0.1% (0.0-0.6) 17.96 (0.13-77.95) 17.83 (0.13-77.42) 137.36 (24.94-338.03)
Treatment only 1.14 (0.02-4.59) 1.2% (0.0-4.4) 21.09 (0.12-86.53) 19.96 (0.11-83.31) 18.56 (5.28-51.96)
Treatment + quality 1.21 (0.09-4.68) 1.3% (0.1-4.5) 26.42 (0.67-93.98) 25.21 (0.57-91.45) 21.77 (5.70-191.78)
Comprehensive 1.35 (0.13-4.83) 1.4% (0.2-4.5) 46.29 (9.13-112.39) 44.95 (8.92-109.14) 34.41 (11.48-244.48)

Estimates are from the global cancer survival microsimulation model.55