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. 2021 Sep 15;184(21):5432–5447.e16. doi: 10.1016/j.cell.2021.09.015

Figure 6.

Figure 6

Mosaic and cocktail RBD-NP vaccines protect against heterotypic SARS-CoV-MA15 challenge in 15-week-old BALB/c cByJ mice

(A) Weight loss following SARS-CoV MA15 challenge up to 4 days post infection (n = 8). Unvaccinated animals are shown as black circles.

(B) Congestion score following SARS-CoV MA15 infection with a score of 0 indicating unchanged lung color and 4 indicating a darkened and diseased lung (n = 8).

(C) Viral titers in mice lungs (expressed in PFUs per lobe) following challenge (n = 8) with an LOD of 9 × 101. LOD is shown as a gray horizontal dotted line. Statistical significance was determined by Kruskal-Wallis and shown when significant. ∗∗p < 0.01.

(D) Mean eosinophils per high power field (HPF) per sample run over 10 HPF per lung stained with congo red. Significance was determined using one-way ANOVA and shown where significant.

(E–I) Histological analysis of stained lung sections for mRBD-NP (E), mRBD-NP-DO (F), cRBD-NP (G), cRBD-NP-DO (H), and unvaccinated mice (I). Arrowheads indicate eosinophils. Scale bar, 20 μm.