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. 2021 Sep 15;184(21):5432–5447.e16. doi: 10.1016/j.cell.2021.09.015

Figure 1.

Figure 1

A single immunization with RBD-NP protects BALB/c cByJ mice from SARS-CoV-2 MA10 challenge

(A and C) S2P-binding Abs were measured 2 (A) or 5 (C) weeks post-prime; teal squares: 2 doses of 0.1 μg (n = 10); filled teal circles: 2 doses of 1 μg (n = 8); open teal circles: one dose of 1 μg (n = 8) with a limit of detection (LOD) of 1 × 102.

(B and D) Serum neutralizing Ab titers at 2 (B) or 5 (D) weeks post-prime determined using an MLV pseudotyping system with an LOD of 3.3 × 101.

(E) Weight loss following SARS-CoV-2 MA10 challenge up to 4 days post infection (n = 8 vaccinated; n = 6 naive mice shown as black filled circles).

(F) Congestion score following SARS-CoV-2 MA10 challenge with a score of 0 indicating unchanged lung color and 4 indicating a darkened and diseased lung.

(G) Viral titers in the mice lungs (expressed in plaque forming units [PFUs] per lobe) following challenge with an LOD of 9 × 101. Statistical significance was determined by Kruskal-Wallis test and shown only when significant. ∗∗p < 0.01. LODs are shown as gray horizontal dotted lines.

Raw data curves shown in Data S1.