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. 2021 Sep 8;12(9):840. doi: 10.1038/s41419-021-04037-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A ROC curves were used to evaluate whether exosomal‐miR‐3157-3p acts as a biomarker. B Representative images of in situ hybridization for miR-3157-3p in the tissues with or without metastasis. C Representative images of miR-3157-3p IHC for CD34 with high or low expression levels of miR-3157-3p. The scale bar in 200× images represents 100 µm. The scale bar in 400× images represents 50 µm. D Schematic diagram of the role of NSCLC-secreted miR- 3157-3p in pre-metastatic niche formation. The data are shown as the mean ± SD.