Figure 1.
Pooled Burden Analysis of Putatively DVs in Patients With AM
(A) A pooled burden analysis of deleterious variant (DV) burden in 3 acute myocarditis (AM) cohorts (AM1, AM2, AM3) identified a statistically significant enrichment of DVs in patients with AM compared with in control subjects (logistic regression odds ratio and 95% CI shown as red diamond; P = 0.003). (B) In a supporting analysis, 10,000 simulations of resampling with replacement within each study based on study sample size (gray) also identified a statistically significant DV burden in patients with AM (odds ratio: 2.48 shown as red line, 95% CI: 1.31-4.54; P = 0.004).