Table 1.
Association results of SLC30A10 Thr95Ile with selected quantitative traits.
| Quantitative trait | Association with SLC30A10 Thr95Ile | |||||
| p | signif. | Effect (SD) | 95% CI lower | 95% CI upper | N | |
| Aspartate aminotransferase | 2.90E−32 | *** | 0.38 | 0.31 | 0.44 | 387,770 |
| Alanine aminotransferase | 1.95E−25 | *** | 0.32 | 0.25 | 0.38 | 389,063 |
| HDL cholesterol | 1.18E−15 | *** | −0.22 | −0.28 | −0.15 | 356,214 |
| Apolipoprotein A | 7.25E−11 | *** | −0.19 | −0.25 | −0.12 | 354,247 |
| Albumin | 2.12E−08 | *** | −0.17 | −0.24 | −0.10 | 356,374 |
| Hemoglobin concentration | 8.11E−06 | ** | 0.09 | 0.04 | 0.15 | 396,065 |
| Hematocrit (percentage) | 1.33E−05 | ** | 0.10 | 0.04 | 0.15 | 396,065 |
| Gamma glutamyltransferase | 9.86E−05 | ** | 0.12 | 0.05 | 0.18 | 388,997 |
| Heel BMD | 2.05E−03 | * | 0.13 | 0.05 | 0.22 | 237,053 |
| Liver MRI: iron-corrected T1 (cT1) | 3.31E−03 | * | 1.22 | 0.48 | 1.96 | 2407 |
Association tests were performed in the White British population. P values are from SAIGE analysis; effect size estimates are from PLINK analysis. (***) indicates genome-wide significance p < 5 × 10−8; (**) indicates phenome-wide significance of p < 3.7 × 10−4; (*) indicates nominal significance of p < 0.05. All traits are rank-based inverse-normal transformed and effect size is in units of standard deviations of the transformed values. Source data for this figure are in Supplementary Data 6.