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. 2021 Jun 7;7(6):1073–1088. doi: 10.1021/acscentsci.1c00440

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© 2021 The Authors. Published by American Chemical Society

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M1-polarized macrophages are more sensitive to tumor-derived extracellular cGAMP. (A) Representative flow cytometry plots identifying the pSTING⁺ populations as a percentage of F4/80⁺/CD206^Low M1 macrophages in tumors from NB and Neu STING groups. (B) pSTING⁺ (left) and pIRF3⁺ (right) cells as a percentage of F4/80⁺/CD206^Low M1 macrophages. (C) Geometric mean of IFNα (left) and IFNβ (right) in F4/80⁺/CD206^Low M1 macrophages. (D) pSTING⁺ (left) and pIRF3⁺ (right) cells as a percentage of F4/80⁺/CD206^High M2 macrophages. (E) Geometric mean of IFNα (left) and IFNβ (right) in F4/80⁺/CD206^High M2 macrophages. (A–F) Data are shown as the mean ± SD, p values were calculated by an unpaired t test with Welch’s correction.