Table 3.
Brain regions showing significantly decreased ROI1-based rs-FC and ROI2-based rs-FC in adolescents with MDD who engage in NSSI compared with the adolescents with MDD only.
| Cluster | Region | Side | Cluster size (voxels) | MNI coordinate | Peak intensity | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| ROI1 | |||||||
| NSSI < MDD | |||||||
| Cluster 1 | ORBsupmed/SFGmed | L/R | 130 | 0 | 63 | 18 | −5.5762 |
| Cluster 2 | PCG | L/R | 40 | −9 | −39 | 27 | −5.4528 |
| ROI2 | |||||||
| NSSI < MDD | |||||||
| Cluster 1 | PAL | L | 61 | −12 | 3 | −3 | −3.8052 |
| Cluster 2 | STG | R | 51 | 63 | −33 | 3 | −4.0349 |
| Cluster 3 | PoCG/IPL | R | 85 | 45 | −39 | 57 | −4.4425 |
MDD, major depressive disorder; NSSI, non-suicidal self-injury; rs-FC, resting-state functional connectivity; MNI, Montreal Neurological Institute; ROI, region of interest; L, left; R, right; ORBsupmed, medial orbital of the superior frontal gyrus; SFGmed, medial superior frontal gyrus; PCG, posterior cingulate gyrus; PAL, pallidum; STG, superior temporal gyrus; PoCG, postcentral gyrus; IPL, inferior parietal lobule.