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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Physiol. 2020 Sep 1;598(21):4887–4905. doi: 10.1113/JP279941

Figure 7. TSPAN-7 regulation of β-cell L-type voltage-dependent Ca2+ channel activity limits GSIS.

Figure 7.

A, average normalized basal (5.6 mM glucose) insulin secretion from dispersed human islets expressing hTSPAN-7 shRNA (light grey; n = 8 human islet donors) relative to scramble shRNA (white; n = 8 human islet donors); P = 0.04. B, average normalized stimulated (14 mM glucose + 45 mM KCl) insulin secretion from dispersed human islets expressing hTSPAN-7 shRNA (light grey; n = 8 human islet donors) relative to scramble shRNA (white; n = 8 human islet donors); P = 0.02. Statistical analysis was conducted using one-sample t tests; uncertainty is expressed as 95% CI.