Figure 1.
Platelet‐derived growth factor (PDGF) ligands and receptors and their effects on the glial lineage. A. Known members of the PDGF families of ligands and receptors; arrows indicate their known in vitro dimerization properties and their interaction with receptors. B. PDGF can induce neural progenitor cells (NPCs) to acquire an oligodendrocyte progenitor cell (OPC) identity. C. PDGF exerts its effects on OPC migration and proliferation by activating different signaling pathways in a concentration‐dependent manner. D. Neuronal and oligodendroglial generation by subventricular zone (SVZ) neural stem cells are regulated by PDGF signaling. CC = corpus callosum; LV = lateral ventricle; OB = olfactory bulb; PDGFR = platelet‐derived growth factor receptor; PI3K = phosphatidylinositol 3‐kinase; PLCγ = phospholipase‐C gamma. References are present for data summarized in B, C and D. The figure was drawn on the bases of the data contained in the cited papers and represents an original artwork.