Figure 3.
Axonal density and axonal damage in periplaque white matter and lesions: Bielschowsky's silver impregnation shows a significantly higher axonal density in PPWM (A) compared to lesions (B). The same is shown by staining for phosphorylated neurofilaments, although numbers are in general lower (SMI‐31, C = PPWM, D = lesion). Injured axons with non‐phosphorylated neurofilaments, as demonstrated by staining with SMI‐32‐antibodies, are found in high numbers in PPWM (E) as well as in lesions (F). However, acutely damaged axons are found in higher numbers in lesions (H) compared to PPWM (G) (APP staining). Original magnification: ×400. Scale bar: 50 m. Patient #262, early active lesion. 210 × 297mm (600 × 600 DPI).