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. Author manuscript; available in PMC: 2021 Dec 23.
Published in final edited form as: Cell. 2020 Dec 9;183(7):1848–1866.e26. doi: 10.1016/j.cell.2020.11.009

Figure 1. MC38 tumor growth is accelerated by HFD feeding in a CD8+ T cell-dependent manner.

Figure 1.

(A) Schematic depicting experimental setup.

(B-E) Tumor growth curves of WT C57BL/6J mice inoculated with 105 MC38 (B), 2x105 E0771 (C), 105 B16 melanoma (D), or 105 Lewis Lung Carcinoma (E) tumor cells.

(F) Tumor growth curves of TCRα-KO mice fed CD or HFD inoculated with 105 MC38 tumor cells.

(G) Tumor growth curves of WT C57BL/6J mice inoculated with 105 MC38 tumor cells and treated with isotype control (left) or depleting anti-CD8 (right) antibodies after CD or HFD feeding for 8-10 weeks.

Data represent ≥ two independent experiments with ≥ 5 mice per group. (*p≤0.05, **p<≤.01, ***p≤0.001, ****p≤0.0001). Graphs display mean +/− SEM (B-G).

See also Figure S1.