Fig. 3. Transient circuit topologies during thalamocortical development.
A. Evoked responses in subplate and L4 after stimulation of the optic radiation in cat (45), of thalamus in mouse thalamocortical slices (15), and in vivo in ferret (39). Responses emerge and latencies are always shortest in SP.
B. Topography is emerging in the subplate. Plotted is the difference in correlation of tuning curves between neighboring recording sites. Early-evoked responses in subplate show differencing responses at larger distances (39).
C: Left: The integration of subplate neurites shows an age-specific pattern (57). Middle: Subplate axons target the septa in S1 barrel cortex (52). Right: Ablating a row of whiskers at birth changed the distribution of the corresponding neurites (57).
D: Various transient connections only present during specific stages of development and not in the adult (34, 40, 59).